Journal Articles

CAR T cell therapy: A new era for cancer treatment (Review)

Rimjhim Mohanty, Chitran Roy Chowdhury, Solomon Arega, Prakriti Sen, Pooja Ganguly, Niladri Ganguly

Pages: 2183-2195 Published online on: 24 September 2019

Cytotoxicity of Cichorium intybus L. metabolites (Review)

Khandaker Md Sharif Uddin Imam, Yingying Xie, Yusi Liu, Fengzhong Wang, Fengjiao Xin

Pages: 2196-2212 Published online on: 24 September 2019

Ibrutinib in CLL/SLL: From bench to bedside (Review)

Fuming Zi, Li Yu, Qingzhi Shi, Aiping Tang, Jing Cheng

Pages: 2213-2227 Published online on: 10 October 2019
Open Access

Role of anabolic agents in colorectal carcinogenesis: Myths and realities (Review)

Theodore Krasanakis, Taxiarchis Konstantinos Nikolouzakis, Markos Sgantzos, Theodore Mariolis‑Sapsakos, John Souglakos, Demetrios A. Spandidos, Christina Tsitsimpikou, Aristidis Tsatsakis, John Tsiaoussis

Pages: 2228-2244 Published online on: 03 October 2019
Open Access

Apurinic endonuclease 1 promotes the cisplatin resistance of lung cancer cells by inducing Parkin‑mediated mitophagy

Zheng Li, Yongqiang Wang, Linbo Wu, Yalu Dong, Jing Zhang, Fan Chen, Wei Xie, Jianguo Huang, Ning Lu

Pages: 2245-2254 Published online on: 01 October 2019
Open Access

Genetic interactions between ANLN and KDR are prognostic for breast cancer survival

Xiaofeng Dai, Xiao Chen, Olivier Hakizimana, Yi Mei

Pages: 2255-2266 Published online on: 24 September 2019
Open Access

Activation of the Toll‑like receptor 2 signaling pathway inhibits the proliferation of HCC cells in vitro

Yi Chen, Zuxiong Huang, Xuzheng Chen, Hanhui Ye

Pages: 2267-2278 Published online on: 27 September 2019
Open Access

Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma

Shu Li, Zhou Jiang, Yirun Li, Yang Xu

Pages: 2279-2292 Published online on: 23 September 2019
Open Access

p53 deficiency augments nucleolar instability after ionizing irradiation

Sangeeta Kakoti, Motohiro Yamauchi, Wenchao Gu, Reona Kato, Takaaki Yasuhara, Yoshihiko Hagiwara, Siddhartha Laskar, Takahiro Oike, Hiro Sato, Kathryn D. Held, Takashi Nakano, Atsushi Shibata

Pages: 2293-2302 Published online on: 27 September 2019
Open Access

Mutations of RAS genes in endometrial polyps

Takashi Takeda, Kouji Banno, Yusuke Kobayashi, Masataka Adachi, Megumi Yanokura, Eiichiro Tominaga, Kenjiro Kosaki, Daisuke Aoki

Pages: 2303-2308 Published online on: 04 October 2019
Open Access

HHLA2 is a novel prognostic predictor and potential therapeutic target in malignant glioma

Yangzhi Qi, Gang Deng, Pengfei Xu, Huikai Zhang, Fanen Yuan, Rongxin Geng, Hongxiang Jiang, Baohui Liu, Qianxue Chen

Pages: 2309-2322 Published online on: 01 October 2019
Open Access

Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma

Akiko Shimbo, Hiroaki Kajiyama, Satoshi Tamauchi, Nobuhisa Yoshikawa, Yoshiki Ikeda, Kimihiro Nishino, Shiro Suzuki, Kaoru Niimi, Jun Sakata, Fumitaka Kikkawa

Pages: 2323-2332 Published online on: 03 October 2019
Open Access

Gene mutation profile and risk stratification in AML1‑ETO‑positive acute myeloid leukemia based on next‑generation sequencing

Guopan Yu, Changxin Yin, Fuqun Wu, Ling Jiang, Zhongxin Zheng, Dan Xu, Jiaheng Zhou, Xuejie Jiang, Qifa Liu, Fanyi Meng

Pages: 2333-2344 Published online on: 15 October 2019
Open Access

Antitumor activity of tetrandrine citrate in human glioma U87 cells in vitro and in vivo

Jingyu Sun, Yang Zhang, Yongzhan Zhen, Ju Cui, Gang Hu, Yajun Lin

Pages: 2345-2354 Published online on: 15 October 2019
Open Access

Acquisition of temozolomide resistance by the rat C6 glioma cell line increases cell migration and side population phenotype

Ya Xu, Xiangcai Yang, Shuting Mei, Yi Sun, Jiejing Li

Pages: 2355-2362 Published online on: 01 October 2019
Open Access

Expression of DR5 and c‑FLIP proteins as novel prognostic biomarkers for non‑small cell lung cancer patients treated with surgical resection and chemotherapy

Hongmei Zheng, Yuting Zhang, Yuting Zhan, Sile Liu, Junmi Lu, Qiuyuan Wen, Songqing Fan

Pages: 2363-2370 Published online on: 04 October 2019
Open Access

miRNA‑183‑5p.1 promotes the migration and invasion of gastric cancer AGS cells by targeting TPM1

Jun Lin, Juan Shen, Hao Yue, Zhongwei Cao

Pages: 2371-2381 Published online on: 04 October 2019
Open Access

Highly sensitive detection of sentinel lymph node metastasis of breast cancer by digital PCR for RASSF1A methylation

Mizuho Abe, Naofumi Kagara, Tomohiro Miyake, Tomonori Tanei, Yasuto Naoi, Masafumi Shimoda, Kenzo Shimazu, Seung Jin Kim , Shinzaburo Noguchi

Pages: 2382-2389 Published online on: 10 October 2019
Open Access

miR‑489 promotes apoptosis and inhibits invasiveness of glioma cells by targeting PAK5/RAF1 signaling pathways

Wei Wang, Luyang Zhang, Wei Gao, Dongyong Zhang, Zilong Zhao, Yijun Bao

Pages: 2390-2401 Published online on: 22 October 2019
Open Access

Construction of a competing endogenous RNA network using differentially expressed lncRNAs, miRNAs and mRNAs in non‑small cell lung cancer

Xi‑Wen Wang, Qi‑Qiang Guo, Yang Wei, Kai‑Ming Ren, Fu‑Shuang Zheng, Jun Tang, Hong‑Yan Zhang, Jun‑Gang Zhao

Pages: 2402-2415 Published online on: 17 October 2019
Open Access

BH3 profiling discriminates the anti‑apoptotic status of 5‑fluorouracil‑resistant colon cancer cells

Kazuma Ishikawa, Yutaka Kawano, Yohei Arihara, Tomohiro Kubo, Kohichi Takada, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Junji Kato

Pages: 2416-2425 Published online on: 15 October 2019
Open Access

Targeting RAD51 enhances chemosensitivity of adult T‑cell leukemia‑lymphoma cells by reducing DNA double‑strand break repair

Meng Yang, Xiaoxue Tian, Zhuoyi Fan, Wenlei Yu, Zheng Li, Jie Zhou, Wenjun Zhang, Aibin Liang

Pages: 2426-2434 Published online on: 22 October 2019
Open Access

Receptor‑interacting serine/threonine‑protein kinase 1 promotes the progress and lymph metastasis of gallbladder cancer

Guangwei Zhu, Qiang Du, Xiao Chen, Xiaoqian Wang, Nanhong Tang, Feifei She, Yanling Chen

Pages: 2435-2449 Published online on: 23 September 2019
Open Access

Systematic profiling of a novel prognostic alternative splicing signature in hepatocellular carcinoma

Dong Zhang, Yi Duan, Zhe Wang, Jie Lin

Pages: 2450-2472 Published online on: 27 September 2019
Open Access

Weighted gene coexpression analysis indicates that PLAGL2 and POFUT1 are related to the differential features of proximal and distal colorectal cancer

Yiming Lv, Binbin Xie, Bingjun Bai, Lina Shan, Wenqian Zheng, Xuefeng Huang, Hongbo Zhu

Pages: 2473-2485 Published online on: 14 October 2019
Open Access

Ku80 gene knockdown by the CRISPR/Cas9 technique affects the biological functions of human thyroid carcinoma cells

Yali Fan, Jianying Li, Wei Wei, Hangrong Fang, Ying Duan, Namiao Li, Yingying Zhang, Jun Yu, Juanhong Wang

Pages: 2486-2498 Published online on: 01 October 2019
Open Access

Effects of CCL5 on the biological behavior of breast cancer and the mechanisms of its interaction with tumor‑associated macrophages

Gaili An, Fang Wu, Shangke Huang, Lu Feng, Jun Bai, Shanzhi Gu, Xinhan Zhao

Pages: 2499-2511 Published online on: 01 October 2019
Open Access

Core‑shell type thermo‑nanoparticles loaded with temozolomide combined with photothermal therapy in melanoma cells

Xiaoyang Hou, Yanyu Pang, Xinxin Li, Chunsheng Yang, Wenlou Liu, Guan Jiang, Yanqun Liu

Pages: 2512-2520 Published online on: 20 September 2019
Open Access

Bradykinin promotes proliferation, migration, and invasion of cervical cancer cells through STAT3 signaling pathways

Wei Wang, Ying Zhou, Rui Wei, Guiying Jiang, Fei Li, Xi Chen, Xueqian Wang, Ding Ma, Ling Xi

Pages: 2521-2527 Published online on: 18 October 2019
Open Access

Exosomes isolated from CAPS1‑overexpressing colorectal cancer cells promote cell migration

Bingrui Wu, Dalong Sun, Lijie Ma, Yiran Deng, Si Zhang, Ling Dong, She Chen

Pages: 2528-2536 Published online on: 09 October 2019
Open Access

Cancer‑associated adipocytes exhibit distinct phenotypes and facilitate tumor progression in pancreatic cancer

Zhiwei Cai, Yun Liang, Chun Xing, Hongwei Wang, Pengfei Hu, Jialin Li, Haiyan Huang, Wei Wang, Chongyi Jiang

Pages: 2537-2549 Published online on: 10 October 2019
Open Access

miR‑425‑5p is associated with poor prognosis in patients with breast cancer and promotes cancer cell progression by targeting PTEN

Sheng Xiao, Hongjia Zhu, Jian Luo, Zhenru Wu, Mingjun Xie

Pages: 2550-2560 Published online on: 14 October 2019
Open Access

β‑elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A‑VEGFA pathway based on network pharmacology

Junqiu Zhu, Bo Li, Yongsuo Ji, Linglin Zhu, Yanfei Zhu, Hong Zhao

Pages: 2561-2571 Published online on: 09 October 2019
Open Access

Comprehensive analysis of the lncRNA‑associated competing endogenous RNA network in breast cancer

Jing‑Jing Wang, Yue‑Qing Huang, Wei Song, Yi‑Fan Li, Han Wang, Wen‑Jie Wang, Min Huang

Pages: 2572-2582 Published online on: 15 October 2019
Open Access

Integrated analysis highlights multiple long non‑coding RNAs and their potential roles in the progression of human esophageal squamous cell carcinoma

Cheng‑Yun Li, Wen‑Wen Zhang, Ji‑Lian Xiang, Xing‑Hua Wang, Jun‑Ling Wang, Jin Li

Pages: 2583-2599 Published online on: 17 October 2019
Open Access

Tex10 promotes stemness and EMT phenotypes in esophageal squamous cell carcinoma via the Wnt/β‑catenin pathway

Xiaocong Xiang, Rong Xiong, Chunlei Yu, Li Deng, Jun Bie, Dongqin Xiao, Zhu Chen, Yuchuan Zhou, Xiaolei Li, Kang Liu, Gang Feng

Pages: 2600-2610 Published online on: 16 October 2019
Open Access

Ammonium tetrathiomolybdate enhances the antitumor effect of cisplatin via the suppression of ATPase copper transporting beta in head and neck squamous cell carcinoma

Shoji Ryumon, Tatsuo Okui, Yuki Kunisada, Koji Kishimoto, Tsuyoshi Shimo, Kazuaki Hasegawa, Soichiro Ibaragi, Kentaro Akiyama, Nguyen Thi Thu Ha, Nur Mohammad Monsur Hassan, Akira Sasaki

Pages: 2611-2621 Published online on: 10 October 2019
Open Access

Identification of TPD52 and DNAJB1 as two novel bile biomarkers for cholangiocarcinoma by iTRAQ‑based quantitative proteomics analysis

Hongyue Ren, Mingxu Luo, Jinzhong Chen, Yanming Zhou, Xiumei Li, Yanyan Zhan, Dongyan Shen, Bo Chen

Pages: 2622-2634 Published online on: 23 October 2019
Open Access

IFN‑β sensitizes TRAIL‑induced apoptosis by upregulation of death receptor 5 in malignant glioma cells

Sodai Yoshimura, Emiko Sano, Yuya Hanashima, Shun Yamamuro, Koichiro Sumi, Takuya Ueda, Tomohiro Nakayama, Hiroyuki Hara, Atsuo Yoshino, Yoichi Katayama

Pages: 2635-2643 Published online on: 22 October 2019
Open Access

Involvement of CHOP in activin A‑induced myeloma NS‑1 cell apoptosis

Jingyan Ge, Hongyan Sun, Jing Li, Yidi Shan, Yang Zhao, Fangwei Liao, Yu Yang, Xueling Cui, Zhonghui Liu

Pages: 2644-2654 Published online on: 22 October 2019
Open Access

Crosstalk between histone modification and DNA methylation orchestrates the epigenetic regulation of the costimulatory factors, Tim‑3 and galectin‑9, in cervical cancer

Li Zhang, Sijuan Tian, Meili Pei, Minyi Zhao, Li Wang, Yifan Jiang, Ting Yang, Juan Zhao, Lihua Song, Xiaofeng Yang

Pages: 2655-2669 Published online on: 24 October 2019

Knockdown of Nedd8‑conjugating enzyme UBE2M suppresses the proliferation and induces the apoptosis of intrahepatic cholangiocarcinoma cells

Bin Zhao, Caiyan Gao, Daixiu Shi, Jie Mao, Jun Zhao, Lingyun Guo, Jiwu Guo, Zuoyi Jiao

Pages: 2670-2679 Published online on: 20 September 2019

Development of recurrence risk score using 95‑gene classifier and its application to formalin‑fixed paraffin‑embedded tissues in ER‑positive, HER2‑negative and node‑negative breast cancer

Yasuto Naoi, Yuria Saito, Kazuki Kishi, Masafumi Shimoda, Naofumi Kagara, Tomohiro Miyake, Tomonori Tanei, Kenzo Shimazu, Seung Jin Kim, Shinzaburo Noguchi

Pages: 2680-2685 Published online on: 07 October 2019

A novel therapeutic anti‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells

So Hee Dho, Eun Ha Cho, Ji Yeon Lee, So‑Young Lee, Sung Hee Jung, Lark Kyun Kim, Jae Cheong Lim

Pages: 2686-2693 Published online on: 26 September 2019

The prednisolone phosphate‑induced suppression of the angiogenic function of tumor‑associated macrophages enhances the antitumor effects of doxorubicin on B16.F10 murine melanoma cells in vitro

Emilia Licarete, Valentin Florian Rauca, Lavinia Luput, Laura Patras, Alina Sesarman, Manuela Banciu

Pages: 2694-2705 Published online on: 01 October 2019

SRPX and HMCN1 regulate cancer‑associated fibroblasts to promote the invasiveness of ovarian carcinoma

Chao Lien Liu, Hung Wei Pan, Pao Ling Torng, Ming Huei Fan, Tsui Lien Mao

Pages: 2706-2715 Published online on: 17 October 2019

Downregulation of MUTYH contributes to cisplatin‑resistance of esophageal squamous cell carcinoma cells by promoting Twist‑mediated EMT

Yanxia Guo, Yuxiu Jia, Shikang Wang, Ning Liu, Dongfang Gao, Lu Zhang, Zhaomin Lin, Shuling Wang, Feng Kong, Chuanliang Peng, Yongqing Liu

Pages: 2716-2727 Published online on: 01 October 2019

Microarray profile of circular RNAs identifies hsa_circRNA_102459 and hsa_circRNA_043621 as important regulators in oral squamous cell carcinoma

Wei Deng, Wei Peng, Tao Wang, Jingxin Chen, Xunding Qiu, Liangbin Fu, Shuangxi Zhu

Pages: 2738-2749 Published online on: 14 October 2019

High levels of Notch intracellular cleaved domain are associated with stemness and reduced bevacizumab efficacy in patients with advanced colon cancer

Francesca Negri, Cecilia Bozzetti, Giuseppe Pedrazzi, Cinzia Azzoni, Lorena Bottarelli, Anna Squadrilli, Costanza Lagrasta, Ione Tamagnini, Alessandra Bisagni, Moira Ragazzi, Rosa Porzio, Gianluca Tomasello, Daniele Mori, Francesco Leonardi, Letizia Gnetti, Pellegrino Crafa, Roberto Sala, Stefano Cascinu

Pages: 2750-2758 Published online on: 01 October 2019

Downregulation of miR‑143 modulates KRAS expression in colorectal carcinoma cells

Hong Liu, Jiansheng Liu, Junkai Huo, Kaihua Li, Kai Li, Haosu Guo, Yirong Yang

Pages: 2759-2767 Published online on: 07 October 2019

Targeting YAP suppresses ovarian cancer progression through regulation of the PI3K/Akt/mTOR pathway

Xiao Wei, Yijuan Jia, Hua Lou, Jingjing Ma, Quanfu Huang, Yunchong Meng, Chaoyang Sun, Zongyuan Yang, Xiaoting Li, Sen Xu, Xin Yang, Teng Ji, Qinglei Gao

Pages: 2768-2776 Published online on: 14 October 2019

RSK4 inhibits breast cancer cell proliferation and invasion in vitro, and is correlated with estrogen receptor upregulation in breast cancer

Hong Huo, Xinqing Ye, Honghe Yang, Qiuyun Li, Yi Jiang

Pages: 2777-2787 Published online on: 20 September 2019

Palmitoylome profiling indicates that androgens regulate the palmitoylation of α‑tubulin in prostate cancer‑derived LNCaP cells and supernatants

Wenqing Li, Junhua Zhang, Lihui Zou, Jian Cui, Fei Su, Junhua Jin, Fei Xiao, Ming Liu, Gang Zhao

Pages: 2788-2796 Published online on: 24 September 2019

Suppressive effects of the sodium‑glucose cotransporter 2 inhibitor tofogliflozin on colorectal tumorigenesis in diabetic and obese mice

Junichi Kato, Yohei Shirakami, Masaya Ohnishi, Taku Mizutani, Masaya Kubota, Hiroyasu Sakai, Takashi Ibuka, Takuji Tanaka, Masahito Shimizu

Pages: 2797-2805 Published online on: 07 October 2019

Follistatin‑like protein 1 knockdown elicits human gastric cancer cell apoptosis via a STAT6‑dependent pathway

Xingang Peng, Peige Wang, Shikuan Li, Yingjun Jiang, Changliang Wu

Pages: 2806-2813 Published online on: 24 September 2019

Οlive tree blossom polyphenolic extracts exert antioxidant and antimutagenic activities in vitro and in various cell lines

Paraskevi Kouka, Fotios Tekos, Kalliopi Valta, Panagiotis Mavros, Aristidis S. Veskoukis, Apostolis Angelis, Alexios-Leandros Skaltsounis, Demetrios Kouretas

Pages: 2814-2825 Published online on: 23 October 2019

Establishment and characterization of a mouse tumor cell line with irreversible downregulation of MHC class I molecules

Karolina Lhotakova, Adrianna Grzelak, Ingrid Polakova, Julie Vackova, Michal Smahel

Pages: 2826-2835 Published online on: 04 October 2019

Potential role for second‑generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia harboring additional clonal chromosome abnormalities: A retrospective CML Cooperative Study Group analysis

Maho Ishikawa, Noriyoshi Iriyama, Michihide Tokuhira, Tomoiku Takaku, Eriko Sato, Kei‑Ji Sugimoto, Tomonori Nakazato, Hiroyuki Fujita, Yuta Kimura, Isao Fujioka, Norio Komatsu, Norio Asou, Masahiro Kizaki, Yoshihiro Hatta, Tatsuya Kawaguchi

Pages: 2836-2843 Published online on: 27 September 2019

DDR1 promotes breast tumor growth by suppressing antitumor immunity

Xing Zhong, Weiwei Zhang, Tianhao Sun

Pages: 2844-2854 Published online on: 27 September 2019
Open Access

[Corrigendum] Lycorine inhibits cell proliferation and migration by inhibiting ROCK1/cofilin‑induced actin dynamics in HepG2 hepatoblastoma cells

Wuyi Liu, Qian Zhang, Qin Tang, Changpeng  Hu, Jingbin  Huang, Yali Liu, Yanyi Lu, Qing  Wang, Guobing  Li, Rong Zhang

Pages: 2856-2856 Published online on: 10 October 2019
Journal Cover

December 2019
Volume 42 Issue 6

Print ISSN: 1021-335X
Online ISSN: 1791-2431

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