Molecular Medicine Reports Special Issues

Human cells: effects of biomaterial scaffolds and 3D printing inks.

Lead Editor:

    Dr Ilaria Dal prã 
    University of Verona
    Italy

Reconstructive medicine requires the choice of biomaterials supporting human cells' viability, growth, and differentiation in a favorable environment capable inducing tissue or organ repair or regeneration according to patients' needs. The purpose of this Issue is to collect original articles and reviews highlighting recent advances in materials science to create an environment as close as possible to the one that human cells produce and in which they live and function.


Submission deadline: 06 July 2023

Molecular Mechanisms and Protective Effects of Natural Agents in Skin Disorders

Lead Editor:

    Professor Seung ho Lee
    Incheon National University
    Republic of Korea

Human skin is an organ plays an important roles in protecting us against external challenges such as ultraviolet (UV) radiation, bacteria, virus, toxic chemicals, and pollutants. These factors can weaken the structure and biological function of skin results in skin aging and pathological skin disorders. In addition, loss of subcutaneous fat by excess exposure to UV rays considered as a crucial cause of metabolic diseases. Therefore, multidisciplinary and combinational approach is essentially needed to develop anti-skin disorder agents. Natural agents including their single constituents (flavonoids, phenolic compounds, and isoflavone etc) have received much attention as a potential candidate for developing safe new drug. Actually, numerous studies have showed the many natural agents which have biological activities against skin disorders and the molecular mechanisms on how they regulate the molecular cascades involved in skin homeostasis have been elucidated. This special issue aim to provide the latest innovative research on functional study of natural agents in skin disorders and it will cover the research topics such as 1. photoaging, 2. oxidative stress on skin, 3. skin regeneration and skim stem cells, 4. skin cancer, 5. skin microbiome, 6. skin inflammation, 7. Immunological disorders in skin.


Submission deadline: 04 July 2023

Tumour microenvironment in anticancer therapy: a new weapon or a blind shot?

Lead Editor:

    Dr Wiktoria Suchorska
    Greater Poland Cancer Centre
    Poland

Cancer is a complex and heterogenous disease with a dynamic interaction between cancer cells and their microenvironment. It is believed that the "tumor microenvironment is not just a silent bystander, but rather an active promoter of cancer progression" (Truffi et al., 2020). Fascinating, dynamic and sometimes very subtle interactions of cancer cells with their microenvironment are essential to stimulate the heterogeneity of cancer cells and clonal evolution. The same interactions have a significant impact on the increase in multidrug resistance or the response to radiation therapy leading to the progression of cancer cells and the formation of metastases. We know more and more about the cancer cells themselves, as well as about their surroundings and its impact on these cells, and consequently on the success of treatment. The question arises whether modifications of the tumor microenvironment can significantly affect the curability of cancer. Or is it a dead end, another in the war against cancer?


Submission deadline: 04 July 2023

Latest advances in diagnosis and prognosis of ovarian cancer

Lead Editor:

    Dr Emmanouil Karteris
    Brunel University
    United Kingdom

Ovarian cancer (OvCa), is one of the most lethal of gynaecological malignancies. The current tools, including measurement of CA125 levels remain problematic. It is clear that there would be tremendous benefit to identifying potential biomarkers and evaluating their diagnostic or prognostic clinical utility. Over the past decade, numerous studies have shown the translational value of liquid biopsies (i.e., blood, saliva, CSF, urine) as an alternative to invasive solid tissue biopsies for several cancers. This special issue aims to serve as a forum for discussing the latest biomarkers developments for OvCa using liquid or tissue biopsies. Manuscripts are invited which critically assess the sensitivity and specificity of potential biomarkers, including the opportunity for monitoring real-time disease dynamics through serial monitoring of OvCa patients. Manuscripts that identify patient-specific molecular landscapes and, therefore, better decide on treatment and determine prognostic outcomes, are also invited. Finally, this special issue can also serve as platform where novel technologies can also be discussed. In summary, this special issue aims to provide a balanced overview of advantages and disadvantages of both tissue and liquid biopsies in OvCa.


Submission deadline: 20 June 2023

Molecular mechanisms underlying cancer: a potential target

Lead Editor:

    Professor Ana Faustino
    University of Évora
    Portugal

Cancer remains as a leading cause of death worldwide, accounting for approximately 10 million deaths in 2020. Cancer develops through four steps, including: initiation, promotion, progression and metastization, and generally it arises from multiple mutations in several genes involved in cells’ growth. Considering this, and the great diversity of cancers, researchers are actively investing their efforts to better understand the molecular mechanisms underlying this disease. Unveiling these mechanisms will for sure allow to improve drug delivery and develop new treatments, with a positive impact in survival rates of cancer patients.


Submission deadline: 20 June 2023

The molecular basis of schizophrenia. An overview. The possible role of immune system, oxidative stress through the gut-brain axis, the nutrition, the viral infection and trauma as a biological footprind

Lead Editor:

    Dr Emmanouil Rizos
    Medical School, National & Kapodistrian University of Athens.
    Greece

Molecular basis of shcizophrenia, the role of oxidative stress, the role of immune system, the role of mirs, of the gut-brain axis, of nutritional factors and the role of chronic stress, virus and trauma in the development of schizphrenia disorder.


Submission deadline: 02 June 2023

Molecular mammalian reproduction

Lead Editor:

    Professor Ayman Swelum
    King Saud University
    Saudi Arabia

Although mammalian reproductive efficiency has improved over the past decades, studying molecular networks involved in reproductive processes is essential. Omics technologies and reproductive systems biology are emerging concepts of molecular reproduction. Omics refers to collective and high-throughput analyses including genomics, transcriptomics, proteomics, and metabolomics/lipidomics that are integrated through robust systems biology, bioinformatics, and computational tools to study the mechanism, interaction, and function of cell populations’ tissues, organs, and the whole organism at the molecular level in a non-targeted and non-biased manner which involved in the regulation of reproductive processes and playing key roles in some sterility and infertility disorders. This Research Topic welcomes ongoing basic and applied research that contributes to discovering, identifying, and/or validating new molecules with potential roles as biomarkers of reproductive physiology, sterility, and infertility disorders. In addition, critical reviews gather current knowledge and upcoming challenges on molecular biomarkers in mammalian reproduction.


Submission deadline: 02 June 2023

Pediatric Pathology Reports in an Fastly Evolving World

Lead Editor:

    Professor Consolato Sergi
    Chief, Anatomic Pathology Division, Pediatric Pathologist, Children’s Hospital of Eastern Ontario (CHEO) Full Professor of Pathology & Pediatrics, Univ. Alberta & Ottawa
    Canada

Pediatric Pathology is a paramount sub-discipline in pathology with an incredible amount of information and experiences related to pediatrics and obstetrics. Translational Pediatrics mirrors and develops the teaching and vision of Professor Fanconi, who embraces the evolution from an exclusively clinical approach to the current Modern Pediatrics and Precision Medicine in Pediatrics. Fanconi spent hours in his laboratory and in his wards recognizing the importance of importing data from bench to bedside. This exchange of information does not need to be reduced to straightforward concepts of future molecular medicine reports but needs to be deeply interlaced with the personalized medicine. Modern Pediatric Pathology relies on the safe shoulders of numerous giants of Pediatrics, Pathology, and Pediatric Pathology. The highly precision-oriented diagnostic and professional pediatric pathology tools are enlarging the range of conditions that can be detected at bedside. Molecular Medicine Reports, specifically in Pediatric Pathology, will be accepted in this special issue.


Submission deadline: 02 June 2023

Treatment options in advanced gynecological cancer

Lead Editor:

    Dr Vasilios Pergialiotis
    National and Kapodistrian University of Athens
    Greece

Advanced gynecological cancer represents one of the most investigated malignancies during the last decade. Once considered untreated with very few options that resided mainly in the field of palliative care, women with gynecological cancer have in our era much more to expect as advances in the surgical and neoadjuvant and adjuvant treatment provide significant survival opportunities. The purpose of the proposed issue is to attract research articles in the field to help enhance current knowledge.


Submission deadline: 01 June 2023

Assessment of redox biomarkers in the evaluation of the antioxidant profile in vitro and in vivo.

Lead Editor:

    Professor Dimitrios Kouretas
    UNIVERSITY OF THESSALY
    Greece

The approach of using redox biomarkers in the evaluation of the antioxidant profile both in vitro and in vivo has come on surface again lately. Although usually overlooked, recent scientific evidence indicates that redox biomarkers can become a useful tool with great translational potency in the field of redox biology. As they have been defined by Veskoukis et al 2019 (10.1016/j.cotox.2018.10.001), a redox biomarker might be an antioxidant molecule modified following interaction with reactive species, the products of the detrimental impact of reactive species on biomolecules and the reactive species per se. Furthermore, terms such as "oxidant" and "pro-oxidant" seem today rather vague as they have not been fully elucidated. On the same basis, the characterization of a compound as "antioxidant" is not sufficient since this term does not denote exactly the biological role of a given substance. Indeed, it is not clear whether the molecule in question prevents oxidation of biomolecules or repairs the oxidative modifications they have already undergone. Towards this end, redox biomarkers can putatively offer a valuable service in this area since, when functionally clustered, they might give the appropriate information for the actual role of an antioxidant. In this special issue, we invite the researchers to contribute both review papers and original research articles that will approach the issue of using biomarkers in order to evaluate on the one hand the antioxidant status of nutritional agents and plant extracts in vitro and on the other hand the redox status of a wide range of organisms in vivo. Potential topics include but are not limited to the following: Biomarkers used for the evaluation of in vivo antioxidant mechanisms Biomarkers for assessing the antioxidant activity of plant compounds in vitro Antioxidant status in disease using redox biomarkers Estimation of redox status in aging The role of redox biomarkers evaluating antioxidant status of a great variety of organisms in the past, present and future Redox biomarkers assessing antioxidant activity: the field of redox biology under a philosophical and historical aspect


Submission deadline: 01 June 2023

Journal Cover

February-2023
Volume 27 Issue 2

Print ISSN: 1791-2997
Online ISSN: 1791-3004

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