Long noncoding RNA IRAIN acts as tumor suppressor via miR‑125b in multiple myeloma

  • Authors:
    • Yanxia Jiang
    • Jian Chen
    • Guoan Chen
  • View Affiliations

  • Published online on: October 21, 2019     https://doi.org/10.3892/ol.2019.11012
  • Pages: 6787-6794
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Abstract

Long noncoding RNAs (lncRNAs) are aberrantly expressed in a variety of cancer types. The lncRNA IGF1R antisense imprinted non‑protein coding RNA (IRAIN) is associated with various cancer types, yet the role of IRAIN in multiple myeloma (MM) progression remains unclear. In the present study it was identified that IRAIN may act as a tumor suppressor in MM, whilst microRNA (miR)‑125b may promote tumorigenesis. Downregulation of IRAIN significantly increased the expression of miR‑125b. Furthermore, by using dual‑luciferase reporter assays, IRAIN was identified as a target of miR‑125b. Knockdown of IRAIN promoted MM cell proliferation in vitro. Thus, expression levels of IRAIN may be used to predict the clinical prognosis of patients with MM and may be a novel therapeutic target for treating MM.

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December 2019
Volume 18 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Jiang, Y., Chen, J., & Chen, G. (2019). Long noncoding RNA IRAIN acts as tumor suppressor via miR‑125b in multiple myeloma. Oncology Letters, 18, 6787-6794. https://doi.org/10.3892/ol.2019.11012
MLA
Jiang, Y., Chen, J., Chen, G."Long noncoding RNA IRAIN acts as tumor suppressor via miR‑125b in multiple myeloma". Oncology Letters 18.6 (2019): 6787-6794.
Chicago
Jiang, Y., Chen, J., Chen, G."Long noncoding RNA IRAIN acts as tumor suppressor via miR‑125b in multiple myeloma". Oncology Letters 18, no. 6 (2019): 6787-6794. https://doi.org/10.3892/ol.2019.11012