Nutritional benefit of laparoscopic jejunostomy during neoadjuvant chemotherapy for obstructing esophageal cancer

  • Authors:
    • Ken Nagata
    • Hironori Tsujimoto
    • Hiromi Nagata
    • Manabu Harada
    • Nozomi Ito
    • Shinsuke Nomura
    • Hiroyuki Horiguchi
    • Shuichi Hiraki
    • Suefumi Aosasa
    • Kazuo Hase
    • Hideki Ueno
  • View Affiliations

  • Published online on: October 16, 2019     https://doi.org/10.3892/mco.2019.1938
  • Pages: 612-616
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Abstract

Neoadjuvant chemotherapy (NAC) confers a survival benefit in esophageal carcinoma, but it is difficult to perform in patients who cannot receive enteral feeding due to an esophageal obstruction. In the current study, the nutritional benefit of laparoscopic jejunostomy (Lap‑J) was evaluated in patients with NAC for obstructing esophageal cancer. A total of 91 patients with esophageal cancer who received NAC between 2009 and 2017 were included in the present study. Lap‑J was performed prior to NAC in 15 patients (16.5%) with an obstructing tumor. Patients with NAC without Lap‑J were used as the control group (n=76). Nutritional parameters and surgical outcomes of the two groups were compared retrospectively. In the patients with Lap‑J, 14 of the 15 patients (93.3%) did not experience any procedure‑associated complications. No mortalities were associated with Lap‑J. Significant decreases in total serum protein, albumin, hemoglobin concentrations and prognostic nutritional index (PNI) occurred following NAC in the control but not in the Lap‑J group. Serum albumin and the improved modified Glasgow prognostic score increased significantly after NAC in the Lap‑J group but not in the control group. In conclusion, perioperative nutritional support with Lap‑J was safe and effective in patients with NAC for obstructing esophageal cancer.

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December 2019
Volume 11 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Nagata, K., Tsujimoto, H., Nagata, H., Harada, M., Ito, N., Nomura, S. ... Ueno, H. (2019). Nutritional benefit of laparoscopic jejunostomy during neoadjuvant chemotherapy for obstructing esophageal cancer. Molecular and Clinical Oncology, 11, 612-616. https://doi.org/10.3892/mco.2019.1938
MLA
Nagata, K., Tsujimoto, H., Nagata, H., Harada, M., Ito, N., Nomura, S., Horiguchi, H., Hiraki, S., Aosasa, S., Hase, K., Ueno, H."Nutritional benefit of laparoscopic jejunostomy during neoadjuvant chemotherapy for obstructing esophageal cancer". Molecular and Clinical Oncology 11.6 (2019): 612-616.
Chicago
Nagata, K., Tsujimoto, H., Nagata, H., Harada, M., Ito, N., Nomura, S., Horiguchi, H., Hiraki, S., Aosasa, S., Hase, K., Ueno, H."Nutritional benefit of laparoscopic jejunostomy during neoadjuvant chemotherapy for obstructing esophageal cancer". Molecular and Clinical Oncology 11, no. 6 (2019): 612-616. https://doi.org/10.3892/mco.2019.1938